Click on the window pull down button and choose Payruns. Press the insert key which will add a new Payrun row. Below the Payrun window, click on the window pull down button and click Pay List. From this table you can delete individual employees from this particular Payrun.
Once you have the correct employees appearing in the Paylist for the Payrun process the Payrun by pressing F3 on Unprocessed.
Future updates to NV2 may include the option to Post and Print.
On a pentium 4 machine with 1 Gig of RAM, processing a Payrun has been quite snappy on my system.